https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51417 Wed 28 Feb 2024 16:32:18 AEDT ]]> Physiological and pharmaceutical considerations for rectal drug formulations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45033 Wed 26 Oct 2022 10:59:52 AEDT ]]> Advantages and limitations of current imaging techniques for characterizing liposome morphology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47474 Wed 24 Jan 2024 14:18:24 AEDT ]]> Advances in oral drug delivery for regional targeting in the gastrointestinal tract - influence of physiological, pathophysiological and pharmaceutical factors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38577 Wed 22 Mar 2023 17:23:53 AEDT ]]> PAIN - Novel targets and new technologies (editorial) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19629 Wed 11 Apr 2018 16:52:46 AEST ]]> Hypoxia-inducible factor (HIF) as a target for novel therapies in rheumatoid arthritis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29816 Wed 11 Apr 2018 16:12:20 AEST ]]> Gabapentin modulates HCN4 channel voltage-dependence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30562 h in brain slice experiments. However, evidence showing that GBP directly modulates HCN channels is lacking. The effect of GBP was tested using two-electrode voltage clamp recordings from human HCN1, HCN2, and HCN4 channels expressed in Xenopus oocytes. Whole-cell recordings were also made from mouse spinal cord slices targeting either parvalbumin positive (PV+) or calretinin positive (CR+) inhibitory neurons. The effect of GBP on Ih was measured in each inhibitory neuron population. HCN4 expression was assessed in the spinal cord using immunohistochemistry. When applied to HCN4 channels, GBP (100 μM) caused a hyperpolarizing shift in the voltage of half activation (V1/2) thereby reducing the currents. Gabapentin had no impact on the V1/2 of HCN1 or HCN2 channels. There was a robust increase in the time to half activation for HCN4 channels with only a small increase noted for HCN1 channels. Gabapentin also caused a hyperpolarizing shift in the V1/2 of Ih measured from HCN4-expressing PV+ inhibitory neurons in the spinal dorsal horn. Gabapentin had minimal effect on Ih recorded from CR+ neurons. Consistent with this, immunohistochemical analysis revealed that the majority of CR+ inhibitory neurons do not express somatic HCN4 channels. In conclusion, GBP reduces HCN4 channel-mediated currents through a hyperpolarized shift in the V1/2. The HCN channel subtype selectivity of GBP provides a unique tool for investigating HCN4 channel function in the central nervous system. The HCN4 channel is a candidate molecular target for the acute analgesic and anticonvulsant actions of GBP.]]> Wed 11 Apr 2018 16:01:42 AEST ]]> Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23246 Wed 11 Apr 2018 15:46:06 AEST ]]> An emerging role for the mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14893 Wed 11 Apr 2018 14:56:12 AEST ]]> Lipid-based nano-delivery systems for skin delivery of drugs and bioactives https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26003 Wed 11 Apr 2018 13:27:41 AEST ]]> Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14215 Wed 11 Apr 2018 13:17:12 AEST ]]> Female reproductive tract pain: targets, challenges, and outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18783 Wed 11 Apr 2018 12:33:36 AEST ]]> Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14569 Wed 11 Apr 2018 10:44:13 AEST ]]> Topical loperamide-encapsulated liposomal gel increases the severity of inflammation and accelerates disease progression in the adjuvant-induced model of experimental rheumatoid arthritis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33962 Wed 04 Sep 2019 10:05:00 AEST ]]> Advances and challenges of liposome assisted drug delivery https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22593 Tue 26 Feb 2019 13:23:46 AEDT ]]> Drug-related problems among transfusion-dependent thalassemia patients: A real-world evidence study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52565 Tue 17 Oct 2023 15:40:59 AEDT ]]> Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43148 Tue 13 Sep 2022 15:29:00 AEST ]]> Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54219 ACTA2), collagen (COL) 1A1 and fibulin-1 (Fbln1) and higher Fbln1 protein deposition after 7 days. Our results show that exposure of lung fibroblasts to fibrotic stiffness activates genes and secreted factors that are part of fibrotic responses and part of the Senescence-associated secretory phenotype (SASP). This overlap may contribute to the creation of a feedback loop whereby fibroblasts create a perpetuating cycle reinforcing progression of a fibrotic response.]]> Tue 13 Feb 2024 11:58:49 AEDT ]]> Australian Sea Snake Envenoming Causes Myotoxicity and Non-Specific Systemic Symptoms - Australian Snakebite Project (ASP-24) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53624 2 years. Information about demographics, bite circumstances, species involved, clinical and laboratory features of envenoming, and treatment is collected and entered into a purpose-built database. Results: Between January 2002 and August 2020, 13 patients with suspected sea snake bite were recruited to ASP, 11 were male; median age was 30 years. Bites occurred in Queensland and Western Australia. All patients were in or around, coastal waters at the time of bite. The species involved was identified in two cases (both Hydrophis zweifeli). Local effects occurred in 9 patients: pain (5), swelling (5), bleeding (2), bruising (1). Envenoming occurred in eight patients and was characterised by non-specific systemic features (6) and myotoxicity (2). Myotoxicity was severe (peak CK 28200 and 48100 U/L) and rapid in onset (time to peak CK 13.5 and 15.1 h) in these two patients. Non-specific systemic features included nausea (6), headache (6), abdominal pain (3), and diaphoresis (2). Leukocytosis, neutrophilia, and lymphopenia occurred in both patients with myotoxicity and was evident on the first blood test. No patients developed neurotoxicity or coagulopathy. Early Seqirus antivenom therapy was associated with a lower peak creatine kinase. Conclusion: While relatively rare, sea snake envenoming is associated with significant morbidity and risk of mortality. Early antivenom appears to have a role in preventing severe myotoxicity and should be a goal of therapy.]]> Tue 12 Dec 2023 15:26:45 AEDT ]]> Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36623 Thu 28 Oct 2021 13:02:10 AEDT ]]> Isolation and Characterization of Two Postsynaptic Neurotoxins From Indian Cobra (Naja Naja) Venom https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51188 Thu 24 Aug 2023 14:39:11 AEST ]]> Variations in the Consumption of Antimicrobial Medicines in the European Region, 2014–2018: Findings and Implications from ESAC-Net and WHO Europe https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53404 Thu 23 Nov 2023 13:44:19 AEDT ]]> The search for novel analgesics: re-examining spinal cord circuits with new tools https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18904 Thu 13 Jun 2024 08:04:55 AEST ]]> Advantages and limitations of current techniques for analyzing the biodistribution of nanoparticles https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43031 Mon 12 Sep 2022 11:35:20 AEST ]]> Antimicrobial medicines consumption in Eastern Europe and Central Asia - an updated cross-national study and assessment of quantitative metrics for policy action https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36795 Mon 06 Jul 2020 15:22:42 AEST ]]> Investigating Toxin Diversity and Abundance in Snake Venom Proteomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48007 Mon 01 May 2023 15:17:16 AEST ]]> Isolation and Pharmacological Characterization of α-Elapitoxin-Oh3a, a Long-Chain Post-Synaptic Neurotoxin From King Cobra (Ophiophagus hannah) Venom https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51342 Fri 01 Sep 2023 13:34:38 AEST ]]>